SVIBOR - Project code: 1-08-320

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
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SVIBOR

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Project code: 1-08-320


In Vivo Effect of Asbestos on Alveolar Macrophage Functional Ability


Main researcher: TROŠIĆ, IVANČICA (50540)


Assistants
Type of research: basic
Duration from: 06/30/92. to 12/31/94.
Papers on project (total): 18
Papers on project quoted in Current Contents: 4
Institution name: Institut za medicinska istraživanja i medicinu rada, Zagreb (22)
Department/Institute: Department for Occupational Health
Address: Ksaverska cesta 2
City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (0)41 214-460
Fax: 385 (0)41 274-572
E-mail: itrosic@mimi.imi.hr
Summary: The biological effect of respirable asbestos fibers, prepared for animal model experiment as well as inert polystirene microspheres on a free lung cell population obtained by bronchoalveolar lavage of intrabronchial instilled experimental animals, will be examined. We anticipate that the results will demonstrate in what way the instilled agents influence the functional ability of phagocytes, and also provide insight of their redistribution among the cells. The presumed development of lung fibrosis in experimental animals will be demonstrated by standard histological methods. The correlation between the concentration of the forementioned agents and the length of exposure with the results of the examined phagocyte functional ability will be determined by using adequate biostatistical methods.

Keywords: lung alveolar macrophage, phagocytosis, clirens, experimental asbestosis, redistribution, occupational asbestosis, pneumoconiosis development mechanisms

Research goals: The aim of the study is to examine the functional ability of lung and alveolar phagocytes exposed to asbestos fibers and inert particles "in vivo". The investigation of the functional ability of phagocytes under the controlled experimental conditions will contribute to better understanding of the role of the phagocytes in the transport, deposition, clearance, retention and redistribution of phagocyted particles, thereby throwing significant light on the mechanical-irritative and physical-chemical theory on the occurrence of mineral dust related diseases. By means of adequate biostatistic tests, important parameters of early detectable biological effects of the applied agents would be established. The primary aim of this study is to provide a significant scientific contribution to the unclear problem of etiology and pathogenesis of lung fibrosis caused by fibrous mineral dusts, as well as in prevention of disability caused by development of occupational pneumoconiosis.

COOPERATION - INSTITUTIONS


  1. Name of institution: Medizinisches Institut fur Umwelthhygiene an der Universitat Dusseldorf
    Type of institution: State institute
    Type of cooperation: Occasional exchange of experts
    City: ., .

OTHER ACHIEVEMENTS


  1. Name: Stipendija Deutscher Akademischer Austaushdienst e.v.Program-a
    Type of achievement: Other
    Authors: Ivančica Trošić
Other information about the project.
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Last update: 10/06/95
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