SVIBOR - Project code: 3-01-100

MINISTRY OF SCIENCE AND TECHNOLOGY

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Project code: 3-01-100


THE INFLUENCE OF RADIOTHERAPY AND CHEMOTHERAPY ON MALIGNANT AND SEMIMALIGNANT GLIOMAS


Main researcher: MARKULIN-GRGIĆ, LJERKA (29401)


Assistants
Type of research: applied
Duration from: 04/01/91. to 04/01/94.
Papers on project (total): 26
Papers on project quoted in Current Contents: 2
Institution name: Medicinski fakultet, Zagreb (108)
Department/Institute: Clinic of Oncology and Radiotharpy, Faculty of Medicine, Zagreb University Clinical Hospital Centre Zagreb, Rebro Hospital
Address: Kišpatićeva 12
City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (01)-233-980
Summary: In the period from 1991.-1994. 158 patients with malignant and semimalignant gliomas were included into the study: 87 male (55.1%) and 71 female (44.8%) patients. The average age was 45 (M:42 y, F:46 y). The higher incidence was observed in the age group 21-30 and 51-60 years. The patients were prospectively randomized into two groups according to the irradiated volume of the brain, to find out wether there is significant differnce in the survival rates, which is still under discussion in the literature. The first group was irradiated by smaller fields, and with relatively higher tumor doses. Into this group until the end of 1994. 83 pts. (52.5%) were included, and the 1 year survival rate for 62 of them treated until the end of 1993. was 75.8%. Out of 41 patients of the same smaller fields group treated until the end of 1992. the 2 years survival rate was 17.1%. Into the second group 75 pts. were included. They were treated by larger fields and respectively with lower tumor doses. The 1 yearsurvival rate for 57 pts. from this group treated until the end of 1993. was 70.2%. The 2 year survival rate for 38 patients treated until the end of 1992. was 15.8%. All the patients were treated by parallel opposed pair of fields, in 16-18 fractions, in 3-3.5 weeks. Out of 158 pts. 107 received postoperative and postirradiation chemotherapy (67.7%). 81/107 pts. were treated by monochemotherapy - CCNU (75.7%), and 26/107 by polichemotherapy - CCNU or BCNU+VCR (24.3%). All the patients were followed up using the own software constructed for the trial by regularly preformed CT scans, EEG-s, neurological and ophtalmological tests and the other tests scheduled by the protocol.

Keywords: Central nervous system neoplasms, Gliomas, Semimalignant gliomas, Malignant gliomas, Radiotherapy, Chemotherapy

Research goals: The aim of this study is to find out the optimum volume of the central nervous system which has to be included into the irradiation field as well as the influence of mono or polichemotherapy on survival of patients with malignant or semimalignant gliomas. The study wants to find out if the three grade staging system for the malignant glimas has influence on the prognosis for these patients. The aim of the study is also to find out the importance of age, sex, size and site of these tumors, as well as the importance of the extent of the surgical treatment (biopsy, paliative tumor reduction , or "radicaltreatment") on the survival.

COOPERATION - INSTITUTIONS


  1. Name of institution: Zavod za neuropatologiju, KBC Rebro, Zagreb
    Type of institution: University/Faculty
    Type of cooperation: Systematic exchange of information
    City: 10000 - Zagreb, Croatia

  2. Name of institution: Klinika za neurokirurgiju KBC Rebro
    Type of institution: University/Faculty
    Type of cooperation: Occasional exchange of information
    City: 10000 - Zagreb, Croatia

  3. Name of institution: Klinika za neurokirurgiju KB "Sestre milosrdnice"
    Type of institution: International organization
    Type of cooperation: Occasional exchange of information
    City: 10000 - Zagreb, Croatia

  4. Name of institution: Klinika za neurokirurgiju KB Firule, Split
    Type of institution: University/Faculty
    Type of cooperation: Occasional exchange of information
    City: 21000 - Split, Croatia

  5. Name of institution: Klinika za neurokirurgiju Klinicke bolnice Dubrava
    Type of institution: Other
    Type of cooperation: Occasional exchange of information
    City: 10000 - Zagreb, Croatia

  6. Name of institution: Christie Hospital and Holt Radium Institute Manchester, UK
    Type of institution: University/Faculty
    Type of cooperation: Systematic exchange of information
    City: M20 9BX - Manchester, United Kingdom
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Last update: 11/26/95
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