SVIBOR - Project code: 3-01-256

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

SVIBOR

SVIBOR - Collecting Data on Projects in Croatia

Project code: 3-01-256


INTERVENTIONAL GASTROENTEROLOGY-USE AND DEVELOPMENT OF NEW TECHNOLOGIES


Main researcher: PULANIĆ, ROLAND (141256)


Assistants
Type of research: developmental
Duration from: 01/01/91. to 12/30/97.
Papers on project (total): 38
Papers on project quoted in Current Contents: 5
Institution name: KBC, Znanstvena jedinica za patobiokemijska i klinička istraživanja, Zagreb (167)
Department/Institute: Ward of interventional gastroenterology, Department of gastro- enterology, Internal clinic Rebro, KBC Zagreb
Address: Kišpatićeva 12
City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (0) 233-233/187
Fax: 385 (0) 223-180
Summary: The aim of our research is to use and develop new gastroenterological, endoscopic and ultrasound technologies that would enable application of new diagnostic and therapeutical procedures. Thus, more qualitative work and incorporation into the international knowledge transfer would be made possible. The formation of hemodyamic laboratory, make us able to determine the risk for the development of esophageal varices and their hemorrhage, and establish the role of liver transplantation as the final method in solving the consequence of portal hypertension. The introduction of transjugular intrahepatic portosystemic stent shunt would extend the field of our work enabling us to effectively treat the patients with portal hypertension. The application of alcohol in primary and metastatic tumors has been introduced. By the launching of this method and doppler ultrasound, follow-up of vascularization and necrosis of a tumor, respectively, has been made possible, what is our modification of the mentioned method. Over the past two years, methods of biliary dranaige and wirsungography under the control of an ultrasound and X-ray have been developed. The introduction of endoscopic biliary dranaige is just under way. The use of endoscopic ultrasound and laser would enable the follow-up of laser efficiency in the treatment of early gastric carcinoma. We would try to produce our own software for endoscopic findings and elaboration of educational video films.

Keywords: New technologies, hemodynamic laboratory, portal hypertension, hepatic tumors, application of alcohol (PEIT), biliary drainage, early gastric carcinomas, endoscopic ultrasound, video-computer-endoscopic lines.

Research goals: The main aim of the project is to introduce and apply new endoscopic and ultrasound technologies in order to enlarge the area and compentence of our work and to enable research within the field of interventional gastroenterology. There are many goals. The first goal is to found a hemodynamic laboratory within wich the changes on the level of portal vein as well as all the complications of portal hypertension by endoscopic, ultrasoun and radiology methods will be followed up. We expect that we will be able to follow-up all the hemodynamic changes in the portal vein pool and assess the risk of the development of varices and hemorrhage by the above mentioned methods. This part of the project will be realised within the PhD thesis. The second goal is to develop and investigate new ways of endoscopic control of bleeding from gastroduodenal ulcers. Besides laser and injection sclerotherapy, we have alredy in 1993 introduced a new method of fibrin glue injection. In this field, we are collaborating with dr. Friedrichs from Duisburg and the firm Behring, Marbur, Germany. We belive that it would be possible to assess the efficacy of particular hemostatic methods for different thypes of ulcer hemorrhage and that the Forrest's classification of bleeding ulcers could be critically evaluated, since it does not completely sutisfy all characteristics of bleeding dynamics. In 1993, we have started to study the relationship between gastric carcinoma (GC) and infection caused by Helicobacter pylori (HP). The potential relationship between HP and the development of GC is under study in the world at present, and we are planing to determine the frequency of this infection and tumors in our population. The next aim of the project is to follow-up the efficiency of laser therapy of early gastric cancer, as a curative methods when surgical procedure is inpossible. We hope that the treatment of patients with early gastric carcinomas will be even more successful with the instituion of endoscopic ultrasound. The futher goal is to modify a method of alcochol injection into the feeding artery of hepatic tumor. We expect that this modification will result in a quicker necrosis of a tumor. The results will be presented in the PhD thesis. During the last year and half, we have started to perform biliary drainage under the control of ultrasound. The aim of this segment of interventional gastroenterology is to expand the way of biliary drainage by help of endoscopy. We are just elaborating our own coputer system for output and storage of endoscopic and ultrasound findings. We are planing to investigate the possibility of use of endoscopic-computer-video system in the work out of films for education in endoscopic and surgical endoscopy and ultrasound.

COOPERATION - INSTITUTIONS


  1. Name of institution: BEHRINGWERKE AG SBU THERAPEUTICS
    Type of institution: State institute
    City: D-3550 - MARBURG, GERMANY

  2. Name of institution: KIRURŠKA KLINIKA KBC REBRO
    Type of institution: Economical/Production
    City: 10000 - Zagreb, Croatia

  3. Name of institution: KLINIKA ZA RADIOLOGIJU KBC REBRO
    Type of institution: Economical/Production
    City: 10000 - Zagreb, Croatia

  4. Name of institution: MIKROBIOLOŠKI LABORATORIJ KBC REBRO
    Type of institution: Economical/Production
    City: 10000 - Zagreb, Croatia

  5. Name of institution: MULTINET-INFORMATIČKI INŽINJERING, PROGRAMI ZA BOLNICE
    Type of institution: Non-profit
    City: 10000 - Zagreb, Croatia

  6. Name of institution: KLINIKA ZA PATOLOGIJU KBC REBRO
    Type of institution: Economical/Production
    City: 10000 - Zagreb, Croatia

OTHER ACHIEVEMENTS


  1. Name: doktorat znanosti
    Type of achievement: Other
    Authors: Roland Pulanić
Other information about the project.
MZT Croatian language SVIBOR Alphabetic list Sorted on project code Sorted on institutions Search help
Ministry of
Science and
Technology		 Croatian
language		 Svibor
homepage		 Alphabetic
list		 Sorted on
project code		 Sorted on
institutions		 Search Help
Last update: 10/15/95
Information: svibor@znanost.hr