SVIBOR - Project code: 3-01-269

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
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Project code: 3-01-269


Metabolic and endocrinologic disturbances in obesity


Main researcher: IVANDIĆ, ANTE (78745)


Assistants
Type of research: applied
Duration from: 10/15/91. to 12/31/94.
Papers on project (total): 15
Papers on project quoted in Current Contents: 2
Institution name: Bolnica, Znanstvena jedinica za klinička medicinska istraživanja, Osijek (127)
Department/Institute: Internal clinic Regional Center for Diabetes, Endocrinology and Metabolic diseas es
Address: Osijek, Huttlerova 4
City: 31000 - Osijek, Croatia
Communication
Fax: 385 (0)54 55 11 11
Phone: 385 (0)54 55 52 22 (700,746)
Summary: In the examination anamnestic, clinical, laboratory and hormonal data will be evaluated in the obese subjects with normal and impaired glucose tolerance and in diabetics: nutritional habits, clinical examination, ECG in the rest and during exercise, expiratory/inspiratory index), sonographic measurement of kidney area, sonographic measurement of sistolic and diastolic parameters of left ventricle, measurement of lipoprotein fractions, creatinin, aminotranspherases, gama GT, HBA1c, insulin , C-peptide, glucagon and growth hormnone, androgens, SHBG, as well as microalbuminuria and dinamic renal scintigraphy. All examinations will be performed in matched control group. Some examination will be repeated after reducing diet and body weight loss to determine reversibility of metabolic and endocrinologic abnormalities and significance of reducing diet. After estimation of magnesium serum and eritrocyte concetrations we will evaluate influence of magnesim on peripheral insulin sensitivity in adipose subjects. Results of the examination will be reported in medical journals, on congresses etc. Untill now five reports have been published and one in the form of summary on the congress. Two doctoral dissertations and two master's thesis had been aproved but not yet finished. Another two examinations are still going on but are not finished.

Keywords: obesity, regional distribution of adipose tissue, glucose tolerance, lipoproteins, insulin, C-peptide, growth hormone, glucagon, androgens, SHBG, renal function

Research goals: Goal of the project is to performe examination of obese persons with respect on regional distribution of adipose tissue and evaluate anamnestic, clinical, laboratory and hormonal data in subjects with normal and impaired glucose tolerance and with diabetes mellitus.Contribution of egsogenic factors such as life style and nutritional habits on the beginning and maintance of obesity will be evaluated. We will try to define obesity as diabetogenic factor and determine significance of adiposity and insulin response in glucose tolerance test. We want to determine significance of reducing diet and body weight loss on reversion of metabolic and endocrinological impairments. We will search for abnormalities in cardiovascular function which could be ethiopathogenic associated with adiposity. Androgens and SHBG will be studied to determine correlation between hyperinsulinemia in OGTT and hyperandrogenismus in obese women. Hemodinamic paramethers of renal function will be investigated to recognize early changes in renal functions in adiposity and impaired glucose tolerance. Magnesium status will be estimated and determine its influence on peripheral insulin sensitivity in obese subjescts and diabetes mellitus. Insulin resistance in muscles and adipose tissue will be determinated in the obese subjects. According to the results of our investigation we will propose the best treatment of obesity including the type of reducing diet and physical activity.
Other information about the project.
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Last update: 10/09/95
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