Etiopathogenic model and genetic prediction of cerebrovaskular diseases
Main researcher
: BRINAR, VESNA (34860) Assistants
ZURAK, NIKŠA (55286)
VRANJEŠ, DAVORKA (47991)
BOŽIČEVIĆ, DUBRAVKO (5005)
Type of research: developmental Duration from: 10/10/91. to 10/10/95. Papers on project (total): 66
Papers on project quoted in Current Contents: 5
Institution name: Medicinski fakultet, Zagreb (108) Department/Institute: Department of Neurology, KBC, Rebro, Laboratory for investigatin vegetative nervous system and cognitive functions Address: Kišpatičeva 12 City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (0)1-2335-595
Fax: 385 (0)1-2335-595
Summary: Investigation was pointed to evaluation of etiopathogenic
concept in cerebrovascular disease, because its appereance and evolution
are still full of controversy. Recent studies pointed to importance of
genetic factors as well as other risk factors. Our recent investigations of
erythrocyte antigens and palmar dermatoglyphs pointed to the importance of
genetic factors. Some unclearness in mutual connections between stroke
appearance and risk factors, as well as recent awareness of programmed cell
death existence, implicates the probability of new stroke concept. There
are possibilities that metabolic changes, which are nowdays still assumed
as primary stroke event, are in fact secondary products of primary neuronal
process.Investigations with precise clinical data about stroke evolution,
circumstances of its beginning, risk factors with special interes in
genetic characteristics, as well as evaluation of progressive and
regressive changes in stroke, in correelation with experimental and recent
clinical data give us implication for etiopathogenic concept different from
concept which is for cerebrovascular disease still valid.Investigations of
cognitive function disturbances in stroke patients is relevant mot only for
evaluation of well known development of vascular dementia, but also for
evaluation of smaller cognitive disfunctions which coudn't be defined by
routine clinical test. Results of rehabilitation training are very
important and based on our investigation, rehabilitation training is
starting as soon as possible, it is individually designed,different in
timing as well as in results in ischemic and hemorrhagic stroke patients.
Research goals: Systemic and comprehensively directed research of
cerebrovascular disease, regarding its exceptional importance in mortality
and morbidity of population. Epidemiologic data pointed to importance of
various risk factors, especially of genetic factors. Our espectation is
that evaluation of genetic factors due to erythrocyte antigen markers, and
palmar dermatoglyps can help in early determination of people with high
risk for stroke. Analyses of digitopalmar dermatoglyphs shows significant
correlations between genetic loci that participate in quantitative traits
of palmar dermatoglyphs and the expected genetic loci that are responsible
for the contitution with greater incidence in cerebrovascular disease
(Bansal et al. 1986). The analyses of phenotype and gene frequencies have
clearly showed that MN genetic locus as well as ABO system have the highes
dicrimination values between stroke patients and control group, while for
RH, Ss and P systems discrimination values were not found.These results
pointed to possibility of new, different concept of stroke in which
pressure of environment is not primary in triggering the cerebrovascular
catastrophe. There must be inherited source with important participation in
this events. Recent findings of programmed cell death existence have
similar implications. Particular attention was directed to investigation of
cognitive functions in patients with good recovery after mild stroke, or in
patients with subclinical manifestations of cerebrovascular disease. Our
expectations are to develope objektive measurements for identifying the
extension and/or progession of subclinical manifestation of vascular
disease. Investigations of vegetative nervous system disturbances are rare
in stroke patients. Design of investigation and our expectations are in
evaluation of reflexive algodistrophy as well as symptoms of sensitive
hyperreflection manifestation in various degree of stroke. Other information about the project.