SVIBOR - Project code: 3-01-410

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

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Project code: 3-01-410

Etiopathogenic model and genetic prediction of cerebrovaskular diseases

Main researcher: BRINAR, VESNA (34860)

Assistants

ZURAK, NIKŠA (55286)
VRANJEŠ, DAVORKA (47991)
BOŽIČEVIĆ, DUBRAVKO (5005)

Type of research: developmental
Duration from: 10/10/91. to 10/10/95.

Papers on project (total): 66
Papers on project quoted in Current Contents: 5

Institution name: Medicinski fakultet, Zagreb (108)
Department/Institute: Department of Neurology, KBC, Rebro, Laboratory for investigatin vegetative nervous system and cognitive functions
Address: Kišpatičeva 12
City: 10000 - Zagreb, Croatia

Communication: Phone: 385 (0)1-2335-595; Fax: 385 (0)1-2335-595

Summary: Investigation was pointed to evaluation of etiopathogenic concept in cerebrovascular disease, because its appereance and evolution are still full of controversy. Recent studies pointed to importance of genetic factors as well as other risk factors. Our recent investigations of erythrocyte antigens and palmar dermatoglyphs pointed to the importance of genetic factors. Some unclearness in mutual connections between stroke appearance and risk factors, as well as recent awareness of programmed cell death existence, implicates the probability of new stroke concept. There are possibilities that metabolic changes, which are nowdays still assumed as primary stroke event, are in fact secondary products of primary neuronal process.Investigations with precise clinical data about stroke evolution, circumstances of its beginning, risk factors with special interes in genetic characteristics, as well as evaluation of progressive and regressive changes in stroke, in correelation with experimental and recent clinical data give us implication for etiopathogenic concept different from concept which is for cerebrovascular disease still valid.Investigations of cognitive function disturbances in stroke patients is relevant mot only for evaluation of well known development of vascular dementia, but also for evaluation of smaller cognitive disfunctions which coudn't be defined by routine clinical test. Results of rehabilitation training are very important and based on our investigation, rehabilitation training is starting as soon as possible, it is individually designed,different in timing as well as in results in ischemic and hemorrhagic stroke patients.

Keywords: Genetic factors, cerebrovascular accident, neurogenic control, hemorrhagic infarction, hemereology, refleksive algodystrophy,memory disturbances.

Research goals: Systemic and comprehensively directed research of cerebrovascular disease, regarding its exceptional importance in mortality and morbidity of population. Epidemiologic data pointed to importance of various risk factors, especially of genetic factors. Our espectation is that evaluation of genetic factors due to erythrocyte antigen markers, and palmar dermatoglyps can help in early determination of people with high risk for stroke. Analyses of digitopalmar dermatoglyphs shows significant correlations between genetic loci that participate in quantitative traits of palmar dermatoglyphs and the expected genetic loci that are responsible for the contitution with greater incidence in cerebrovascular disease (Bansal et al. 1986). The analyses of phenotype and gene frequencies have clearly showed that MN genetic locus as well as ABO system have the highes dicrimination values between stroke patients and control group, while for RH, Ss and P systems discrimination values were not found.These results pointed to possibility of new, different concept of stroke in which pressure of environment is not primary in triggering the cerebrovascular catastrophe. There must be inherited source with important participation in this events. Recent findings of programmed cell death existence have similar implications. Particular attention was directed to investigation of cognitive functions in patients with good recovery after mild stroke, or in patients with subclinical manifestations of cerebrovascular disease. Our expectations are to develope objektive measurements for identifying the extension and/or progession of subclinical manifestation of vascular disease. Investigations of vegetative nervous system disturbances are rare in stroke patients. Design of investigation and our expectations are in evaluation of reflexive algodistrophy as well as symptoms of sensitive hyperreflection manifestation in various degree of stroke.

Other information about the project.


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