SVIBOR - Project code: 3-01-518

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

SVIBOR

SVIBOR - Collecting Data on Projects in Croatia

Project code: 3-01-518


MICROVASCULAR ALTERATIONS IN SYSTEMIC CONNECTIVE TISSUE DISEASES


Main researcher: BRUMEN, VLATKA (119715)


Assistants
Type of research: basic
Duration from: 11/10/93. to 12/31/94.
Papers on project (total): 19
Papers on project quoted in Current Contents: 3
Institution name: Institut za medicinska istraživanja i medicinu rada, Zagreb (22)
Department/Institute: Occupational Medicine Department IMR & Division of Clinical Immunology & Rheumatology, Medicine Department, Medical College University of Zagreb
Address: Jordanovac 104, Kišpatićeva 12
City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (0)1-434-188, 223-180
Fax: 385 (0)1-274-572, 223-180
Summary: The research is aimed at investigating of microcircular alterations in systemic connective tissue diseases on the basis of extensive clinical and corresponding experimental studies. Findings obtained by the peripheral blood flow survey, clinical and laboratory analysis, pathohistology and cytogenetic methods will be mutually compared in order to establish a possible correlation among those. The primary goal of the study is an attempt to establish our own criteria for the interpretation of microvascular impairments in systemic connective tissue diseases based upon the evaluation of results obtained among statistically relevant selected population group and a matched number of healthy controls, through quantification of basically semiquantitative methods. A study designed in this way is aimed not only at claryfing the unresolved problem of systemic connective tissue diseases' ethiopathogenesis, but also at improving their early diagnosis and therapy in everyday medical practice.

Keywords: Connective tissue diseases, microvessels

Research goals: Due to the current belief that microvascular impairments underlie the development of SCTD, those changes will be the subject of extensive clinical and corresponding experimental studies in a selected population group and matched healthy controls. Biological study will necessarily be limited to the observation of secondary effects of potent vasoactive substances applied onto the experimental animal, and of the effects of drugs commonly used in the therapy of the SCTD. The drug effect will be evaluated from the aspect of primary microvessel changes, and from the aspect of their genotoxicity. Microvascular changes will be detected stereomicroscopically in vivo, and pathohistologically, upon sacrifizing the experimental animal. Genotoxic effect will be verified by the conventional structural chromosomal aberration analysis and by the sister chromatid exchange method. Microvessel changes in the selected population groups will be determined by a serial application of capillaroscopy, dermothermometry and photoplethysmography in each examinee. These findings will be compared with those obtained by clinical and laboratory analyses, mutagenetic tests and eponichial biopsy. The study is aimed not only at clarifying the scientific problem of the SCTD ethiopathogenesis, but also at improving their early diagnosis and therapy.

COOPERATION - PROJECTS


  1. Name of project: 3-01-402 Psihosocioepidemiološka istraživanja u sistemskim bolestima veziva
    Name of institution: Medicinski fakultet Sveučilišta u Zagrebu
    City: 10000 - Zagreb, Croatia

COOPERATION - INSTITUTIONS


  1. Name of institution: Medicinski fakultet Sveučilišta u Zagrebu, KBC
    Type of institution: University/Faculty
    Type of cooperation: Joint project
    City: 10000 - Zagreb, Croatia
Other information about the project.
MZT Croatian language SVIBOR Alphabetic list Sorted on project code Sorted on institutions Search help
Ministry of
Science and
Technology		 Croatian
language		 Svibor
homepage		 Alphabetic
list		 Sorted on
project code		 Sorted on
institutions		 Search Help
Last update: 10/10/95
Information: svibor@znanost.hr